看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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- T3 ?8 Y5 y' ]5 \3 G: v9 l) ]8 Y& hCurrently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data & y0 V2 q+ d7 C7 V/ K
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+ l; ^ ]' P2 O, X hBevacizumab + sorafenib Yes, reduced dose
1 v( d7 u* \( a, @Bevacizumab + sunitinib† No
) i1 O/ B; a/ OBevacizumab + temsirolimus Yes 8 P3 g. y* d" l8 x& N2 ~8 x5 C8 V
Bevacizumab + everolimus Yes
5 e/ z) w( V2 @/ xSorafenib + sunitinib ? 6 d( ?9 r3 Y% O
Sorafenib + temsirolimus Yes, reduced dose
3 v4 j. M' J1 l/ X) ~. eSorafenib + everolimus Yes, reduced dose
/ Y4 F' {) t1 K0 d; uSunitinib + temsirolimus† No 4 e, c6 J! B2 D" N2 L6 ~4 y
Sunitinib + everolimus ? * Q+ ?# @7 q# R2 J' c
Temsirolimus + everolimus ? ' u( o0 r$ u1 D& ? n5 B7 d
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; G! D4 ]+ `/ O. j9 V8 w, K2 M7 G( D†Led to US FDA warning.# V3 x& l9 p j& i
?: As yet unattempted combination.4 T0 \$ }! Z( j, r
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