发给老马备查:; w! L9 ~* {, O4 ^9 c1 X
滴水察海(69304838) 15:23:23
: g! v+ T! i8 D9 q( p' E老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; D O, H: V& R |5 r( g; T吉非替尼和S-1连用的依据% L8 M# p; r2 i. M" d
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.) q# _ r6 _& T7 M; x
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达5 F$ S1 b R3 R# f( t
这样是不是推理出,耐药后,可以用S-1和培美了?
5 k# w7 P9 z5 x6 P结论:
8 V4 z) Y% J( D如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |