发给老马备查: `* ^3 N; w+ W
滴水察海(69304838) 15:23:23
# T- W1 @( g' M7 j! [. n, L) m老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 Q- w* U$ k, p% s9 L8 Z; a3 \
吉非替尼和S-1连用的依据 A/ x! T o5 E- t
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.- v! d4 \( o" G. s" n, [1 K. P# o
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 m+ ]" `6 [6 a0 L# ~# \# u$ `$ o c
这样是不是推理出,耐药后,可以用S-1和培美了?
+ }" @) l3 u" s/ c结论:/ Y5 s. S/ E# \( ~
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |